A <i>m</i>-quaterphenyl probe for absolute configurational assignments of primary and secondary amines.

ABSTRACT: We report a method for determining the absolute configurations of chiral amino alcohols, amino acid esters, and secondary amines through the combined use of a m-quaterphenyl probe 1 and theoretical calculations. The probe 1 is covalently attached to chiral amines to form conjugates that exhibit exciton-coupled circular dichroism (ECCD) in the m-quaterphenyl chromophores. The calculated ratios of the P and M conformers, obtained via DFT calculations, show a correlation with both the sign and intensity of the experimentally observed CD spectra.

SUBMITTER: Takeuchi Y 

PROVIDER: S-EPMC12557418 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature