Utility of coronary artery calcium scoring in low-risk patients: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Background

Guidelines recommend consideration of coronary artery calcium (CAC) scoring in intermediate atherosclerotic cardiovascular disease (ASCVD) risk patients, but its utility in lower-risk individuals is less clear.

Methods

Data from 6712 participants from MESA was used with 10-year ASCVD risk defined by the pooled cohort equations (PCE) and AHA PREVENT equations. The association between CAC, CHD and ASCVD risk was evaluated using Cox proportional hazard models. Risk prediction improvement was evaluated using Harrell's C-index and net reclassification improvement (NRI).

Results

Amongst all participants (mean age 62.2 ± 10.2 years, 52.8 % women), the ASCVD event rate per 1000 person years was 14.3 vs. 4.1 with and without CAC over a median of 16.7 years. CAC scor

SUBMITTER: Davis JR 

PROVIDER: S-EPMC12557561 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature