Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis.

ABSTRACT:

Background & aims

Anatomical resection (AR) for hepatocellular carcinoma (HCC) could improve micrometastasis eradication and reduce their recurrence, but conflicting findings suggest heterogeneous treatment effects (HTEs). This study investigated the heterogeneity in the association between AR and decreased postoperative HCC recurrence.

Methods

Between January 2014 and December 2021, preoperative imaging and clinicopathologic data from 1,859 patients with HCC were retrospectively reviewed from seven hospitals in China. Using data from six centers (the development set), causal forest modeling was performed to estimate subgroups with different HTEs after propensity score matching (PSM) for multiple clinical-radiological covariates. Differences in early recurrence risk (within

SUBMITTER: Meng XP 

PROVIDER: S-EPMC12557568 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature