SIGLEC15 modulates the immunosuppressive microenvironment and suppresses malignant phenotypes in triple-negative breast cancer.

ABSTRACT: Previous studies have demonstrated a significant association between sialic acid binding Ig-like lectin 15 (SIGLEC15) and both the progression of malignant tumors and immune infiltration. This study comprehensively analyzed and elaborated the function and related mechanism of SIGLEC15 in breast cancer. We analyzed SIGLEC15 expression levels and predicted its functions using mRNA sequencing in a population-based dataset. Single-cell RNA sequencing was utilized to investigate the biological roles of SIGLEC15 within the tumor microenvironment (TME). Finally, we conducted both in vivo and in vitro experiments to validate the findings derived from the RNA sequencing analyses. Elevated SIGLEC15 expression was associated with favorable outcomes in

SUBMITTER: Tan Z 

PROVIDER: S-EPMC12557572 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature