Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novel <i>OptrA</i> variant and regional emergence of an ST9 lineage co-circulating with international CC398 lineages.

ABSTRACT:

Introduction

Staphylococcus aureus (SA) colonizes both humans and animals. The spread of livestock-associated methicillin-resistant S. aureus (LA-MRSA) in farms and the environment poses a public health concern. While CC398 is globally predominant, regional variation exists, and data from Argentina remain scarce. This study investigated the presence, antimicrobial resistance (AMR), and genomic features of pig-associated MRSA in central Argentina, including transmission dynamics and the global phylogenetic context of LA-MRSA lineages CC398 and CC1/ST9.

Methods

Between February and March 2022, 41 MRSA isolates were recovered from 50 fecal and effluent samples collected from 8 of 10 (80%) farrow-to-finish pig farms in Córdoba province, Argentina. Phenotypic suscep

SUBMITTER: Gonzalez MJ 

PROVIDER: S-EPMC12557574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature