The impact of the toll-like receptor 1 (TLR1) variation rs5743557 on tuberculosis susceptibility in the Thai population.

ABSTRACT:

Background

Tuberculosis (TB) remains a major public health concern in Thailand and worldwide. Genetic factors, including single nucleotide polymorphisms (SNPs), play a part in influencing susceptibility to TB. The aim of this study was to investigate the allele and genotype frequencies of the rs5743557 (G>A) polymorphism and its potential impact on TB susceptibility in the Thai population.

Methods

A total of 149 leftover peripheral blood mononuclear cell (PBMC) samples were collected and divided into two groups: patients with TB (TB group, n=92) and patients without TB (non-TB group, n=57). TaqMan real-time polymerase chain reaction (PCR) was performed for genotyping. Logistic regression analysis was performed to assess the association between rs5743557 (G>A) and susceptibil

SUBMITTER: Saengchart C 

PROVIDER: S-EPMC12557648 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature