Predictive model for inhaled corticosteroid response in hospitalized asthma: implications for precision medicine.

ABSTRACT:

Background

Inhaled corticosteroids (ICS) are effective in reducing symptoms and preventing exacerbations in asthma patients and are therefore used as the first-line therapy for asthma management. However, patients show varying responses to ICS treatment, and some patients may require treatment escalation to systemic corticosteroids (SCS) during the follow-up period. The present study aimed to develop an early prediction model for ICS responsiveness by identifying patients initially treated with ICS who later required treatment escalation to SCS. Additionally, we examined the association between clinical features and ICS responsiveness and provided evidence supporting the potential overuse of SCS.

Methods

The study included 5,463 asthma patients (age ≥12 years) who received I

SUBMITTER: Liu D 

PROVIDER: S-EPMC12557650 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature