Second acute exacerbation of fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Few studies have specifically examined on the second acute exacerbation (AE) in patients with fibrotic hypersensitivity pneumonitis (HP) and those with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the incidence and risk factors for the second AE.

Methods

This retrospective study included patients diagnosed histopathologically with fibrotic HP or IPF at Kanagawa Cardiovascular and Respiratory Center between January 2005 and June 2023. The incidence, risk factors, and 90-day survival following the second AE were analyzed.

Results

The cumulative incidence of the first AE was significantly lower in the fibrotic HP group compared with the IPF group [hazard ratio (HR) =0.561, 95% confidence interval (CI): 0.383-0.821, P=0.003]. For the sec

SUBMITTER: Haga S 

PROVIDER: S-EPMC12557668 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature