Intervention of traditional Chinese medicine San-Feng-Tong-Qiao-Di-Wan on allergic rhinitis: a network pharmacology and metabolomics study.

ABSTRACT:

Background

San-Feng-Tong-Qiao-Di-Wan (SFTQDW) is a patented compound Chinese medicine used for acute and chronic rhinitis with few side effects. Its key components have antiallergic activity, making it potentially suitable for allergic rhinitis (AR). However, there is a lack of systematic research on its efficacy and mechanism of action for AR. This study aims to evaluate the potential and mechanism of SFTQDW in treating AR using network pharmacology, AR animal models, clinical observation, and serum metabolomics.

Methods

Network pharmacology was used to screen active ingredients and targets, followed by an AR mouse model study comparing SFTQDW 3.00 vs. 1.45 mg/g body weight vs. control. In a clinical substudy nested within an active-controlled trial, 35 AR pat

SUBMITTER: Chen H 

PROVIDER: S-EPMC12557684 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature