Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers.

ABSTRACT:

Objective

The gastrointestinal (GI) tract is densely innervated, forming a critical network that secretes neuropeptides essential for gut function. Tumour cells are highly adaptive and exploit their microenvironment, including nerves, to support and accelerate growth. However, the mechanisms by which tumour cells interact with neuropeptides in human GI cancers remain poorly understood. We aimed to investigate the expression and function of the sensory neuropeptide calcitonin gene-related peptide (CGRP) and its receptor component, receptor activity-modifying protein 1 (RAMP1), and to elucidate novel mechanisms by which cancer cells exploit neuropeptides.

Methods and analysis

We analysed 180 patient samples using multiplex immunohistochemistry to assess CGRP and RAMP1 expressi

SUBMITTER: Parathan P 

PROVIDER: S-EPMC12557745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature