Unisexual reproduction in the global human fungal pathogen <i><i>Cryptococcus neoformans</i></i>.

ABSTRACT: The human fungal pathogen Cryptococcus species complex (encompassing Cryptococcus neoformans, Cryptococcus deneoformans, and the Cryptococcus gattii species complexes) exhibits diversity in sexual reproduction, including α-a mating, pseudosexual reproduction, as well as unisexual reproduction initiated from a single isolate or between isolates of the same mating type. A central conundrum is that while most Cryptococcus natural populations exhibit significant α mating-type bias, genetic and genomic analyses show recombination occurs in nature. The discovery of unisexual reproduction in C. deneoformans provided insight; however, thus far, unisexual reproduction has never been directly observed in the predominant global pat

SUBMITTER: Sun S 

PROVIDER: S-EPMC12557769 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature