Ultrasound-guided core needle biopsy of the parotid gland in Sjogren's disease: a promising tool towards precision medicine.

ABSTRACT:

Background

Disappointing outcomes in Sjögren's disease (SjD) trials underscore the need for reliable, sensitive endpoints. Histological assessment holds promise, but a minimally invasive, repeatable method for salivary gland tissue sampling is lacking.

Objectives

To evaluate the feasibility, safety and tissue adequacy of ultrasound-guided core needle biopsy (US-guided CNB) of the parotid gland and explore its role for facilitating histology-driven stratification and precision medicine.

Methods

In the Belgian Sjögren's Syndrome Transition Trial, 66 patients (64 without gland swelling) underwent US-guided CNB. US was evaluated using OMERACT (Outcome Measures in Rheumatology Clinical Trials). and Hocevar scoring. Histopathology included assessment of focus score, B cell

SUBMITTER: Achten H 

PROVIDER: S-EPMC12557792 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature