Distinct trajectory of gut microbiota driven by a human oral commensal: insights from a murine study.

ABSTRACT:

Background

Oral microbes modulate the gut microbiota. Haemophilus parainfluenzae, a core human oral commensal with immunomodulatory properties, is reduced in autoimmune diseases, while mitigating Sjögren's syndrome-like disease with improved oral microbiota in female NOD mice. However, whether it modulates the gut microbiota remains unknown.

Objective

To study the modulatory effect of oral H. parainfluenzae inoculation on the gut microbiota.

Design

Female NOD mice were orally inoculated with H. parainfluenzae following antibiotic treatment. Fecal samples were collected pre- and post-inoculation for 16S rRNA gene sequencing. Splenic antigen-presenting cells were analyzed for systemic immunomodulation.

Results

Despite prominent convergence of

SUBMITTER: Lin WT 

PROVIDER: S-EPMC12557821 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature