Fosphenytoin may be effective in shortening the half-life of lamotrigine in case of overdose: a case report.

ABSTRACT:

Background

This case study highlights the efficacy of fosphenytoin in managing cardiac arrest and seizures caused by lamotrigine overdose. While activated charcoal and sodium bicarbonate are typically recommended for lamotrigine overdose, alternative treatment options are scarce if these measures prove ineffective. The half-life of lamotrigine at normal therapeutic doses has been reported to be shortened by the concomitant use of drugs that promote glucuronidation. However, there are currently no reports on the use of these drugs in cases of lamotrigine overdose. It was hypothesized that fosphenytoin, in addition to its anticonvulsant effects, promotes the glucuronidation of lamotrigine and may be effective in patients experiencing lamotrigine overdose.

Case presentation

A 2

SUBMITTER: Sato J 

PROVIDER: S-EPMC12557843 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature