Development and evaluation of a risk calculator for fracture-related infection after open reduction and internal fixation: a multi-institutional study.

ABSTRACT:

Background

Fracture-related infection (FRI) and subsequent persistent infections significantly affect fracture surgeries. We aimed to develop a precise, personalized risk calculator to assist orthopedic surgeons in evaluating perioperative FRI risk.

Methods

Data from 36,087 patients across two medical centers and four regional hospitals were analyzed. We assessed 29 risk factors, including patient characteristics, comorbidities, fracture location, and surgical variables using multivariable logistic regression. Each factor was weighted based on its regression coefficient. Discrimination and calibration were assessed with optimism-corrected AUC and Brier scores (1 000-fold bootstrap) and calibration plots.

Results

FRI occurred in 2396 patients (6.64%), and 453 patients

SUBMITTER: Liao CY 

PROVIDER: S-EPMC12557870 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature