Ontology highlight
ABSTRACT:
SUBMITTER: Rada C
PROVIDER: S-EPMC125579 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20010801 16
Somatic hypermutation, essential for the affinity maturation of antibodies, is restricted to a small segment of DNA. The upstream boundary is sharp and is probably related to transcription initiation. However, for reasons unknown, the hypermutation domain does not encompass the whole transcription unit, notably the C-region exon. Since analysis of the downstream decay of hypermutation is obscured by sequence-dependent hot and cold spots, we describe a strategy to minimize these fluctuations by c ...[more]