Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study.

ABSTRACT:

Background

Ischemic stroke (IS) ranks as the leading cause of disability and the second cause of mortality in adults worldwide. This investigation aimed to describe the fingerprint of immunoglobulin G (IgG) N-glycans and feature of circulating inflammatory cytokines that were associated with the progression of IS, as well as to screen potential biomarkers for screening individuals at higher IS risk.

Methods

A prospective cohort, Liaocheng City Stroke Risk Cohort (LCSRC), was launched in December 2014, in which 1,599 healthy participants were enrolled from Liaocheng People's Hospital (LPH). During nine years of follow-up, 67 participants who were diagnosed with IS were enrolled in the case group. Meanwhile, 201 individuals who did not develop IS were randomly selected as the

SUBMITTER: Sun S 

PROVIDER: S-EPMC12557912 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature