Study on the dynamic changes in antinuclear antibody spectrum in SARS-CoV-2 infection: a retrospective analysis.

ABSTRACT:

Background

Patients with COVID-19 often produce multiple autoantibodies that impact immune function. This study aimed to assess changes in immune status and correlation with SARS-CoV-2 infection by analyzing dynamic shifts in patients' antinuclear antibody (ANA) profiles.

Methods

A retrospective analysis was conducted on ANA data and clinical characteristics of 680 patients with novel coronavirus pneumonia admitted to Taizhou Enze Medical Center (Group) between December 7, 2022, and January 31, 2023. The analysis covered three phases: early COVID-19 (within one year before admission, T1), COVID-19 phase (during hospitalization, T2), and late COVID-19 (within one year after discharge, T3). ANA quantification was primarily performed using indirect immunofluorescence, and the m

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12557972 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature