Curcumin-like diarylpentanoid analogues exhibit antiviral and anti-inflammatory activities in influenza A virus-infected A549 lung epithelial cells by inhibiting multiple retinoic acid-inducible gene I (RIG-I)-mediated pathways.

ABSTRACT: Influenza A virus (IAV) causes seasonal epidemics and occasionally pandemics. Curcumin, a well-known phytochemical, has been reported to exhibit anti-IAV effects; however, most studies were not comprehensive and utilized Mardin-Darby canine kidney (MDCK) cells. Curcumin-like diarylpentanoid analogues, namely 2-benzoyl-6-(3,4-dihydroxybenzylidene)cyclohexen-1-ol (BDHBC) and 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), exhibit improved drug-like properties, including increased solubility and stability, along with stronger antiviral effects against rhinovirus (RV). Thus, this study evaluates the antiviral and anti-inflammatory activities of BDHBC and DHHPD using A549 lung epithelial cells infected with influenza A/Puerto Rico/8/34 (H1N1), and compared the

SUBMITTER: Liew KY 

PROVIDER: S-EPMC12557979 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature