Effect of perioperative intranasal insulin on postoperative delirium in elderly hip fracture patients undergoing general anesthesia: a randomized controlled study.

ABSTRACT:

Objective

Postoperative delirium (POD) frequently occurs among elderly patients following surgery, yet effective preventive measures remain insufficiently established. This study aimed to investigate whether perioperative intranasal insulin (INI) administration could reduce the incidence of POD and modulate inflammatory marker levels in elderly patients undergoing hip fracture surgery under general anesthesia (GA).

Methods

From June to December 2024, a total of 96 elderly patients scheduled for hip fracture surgery with GA were enrolled and randomly assigned to two groups (48 per group). Patients in the insulin group received INI (20 units in 0.5 mL) twice daily, beginning two days preoperatively and continuing for five days. Patients in the control group received an equival

SUBMITTER: Wang J 

PROVIDER: S-EPMC12557987 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature