Molecular landscape and clinical correlates of olfactory groove meningiomas: a multi-institutional study.

ABSTRACT:

Objective

The aim of this study was to investigate the relationship between the clinical and radiological characteristics of olfactory groove meningiomas (OGMs) and their molecular profiles.

Methods

The authors performed targeted next-generation and whole-genome sequencing in 123 OGM samples collected from 4 international institutions, focusing on known meningioma-driver genes. They compared the molecular data with the clinical and radiographic features of the tumors. Patient and tumor data, including age, sex, radiological features, and overall survival, were retrospectively collected and analyzed.

Results

The study cohort comprised 90 females (73%) and 33 males (27%), with a median age at diagnosis of 57 years (range 25-87 years). The majority of tumors (88.6%, n =

SUBMITTER: Alkhatib M 

PROVIDER: S-EPMC12558015 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature