Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.

ABSTRACT:

Aims

We examined whether anticholinergic overactive bladder (OAB) medications are associated with emergency hospital admissions with delirium in adults without dementia.

Setting

England's primary care linked to inpatient records.

Methods

The source population comprised 215 293 adults initiating anticholinergic OAB medications (e.g. oxybutynin, solifenacin and tolterodine) during July 2010-December 2019 when aged ≥50 years, without dementia, severe mental illness or <12 months registration. We conducted self-controlled case-series including 1831 men and 1954 women with emergency hospital admissions with delirium. Incidence rate ratios (IRR) were estimated in risk periods during 6 months before and 12 months after initiating OAB medications, adjusted for time-varying ag

SUBMITTER: Richardson K 

PROVIDER: S-EPMC12558043 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature