Causal inference of modifiable lifestyle and birth traits on osteonecrosis risk: A bidirectional 2-sample Mendelian randomization study.

ABSTRACT: Osteonecrosis (ON) is a progressive skeletal disorder caused by impaired bone perfusion and cell viability. While corticosteroid use and alcohol intake are established risk factors, the causal effects of modifiable lifestyle behaviors and early developmental traits on ON remain unclear. We conducted a bidirectional 2-sample Mendelian randomization (MR) study to assess the causal impact of grape intake, cereal intake, water intake, physical activity amplitude, birth weight, and birth length on ON risk. Summary-level genetic data were obtained from large genome-wide association studies. The inverse-variance weighted method was primary, with MR-Egger and weighted median approaches for sensitivity analyses. False discovery rate (FDR) correction was applied. Forward MR showed that genetically p

SUBMITTER: Xu B 

PROVIDER: S-EPMC12558184 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature