Effect of MEFV mutations and HLA-B27 on clinical findings of familial Mediterranean fever and spondyloarthritis.

ABSTRACT: This study investigated the coexistence of familial Mediterranean fever (FMF) and spondyloarthritis (SpA), aiming to provide a comprehensive understanding of their clinical, radiological, and genetic features. A total of 127 patients with both FMF and SpA were evaluated, with data collected on demographic, clinical, and laboratory characteristics, including human leukocyte antigen (HLA)-B27 status, Mediterranean fever (MEFV) gene variants, and acute phase reactants. Pelvic radiographs and sacroiliac joint magnetic resonance imaging scans were reviewed when available. The median age of the cohort was 39 years (interquartile range: 30-50), and 48% were female, showing an equal sex distribution. Ankylosing spondylitis was the most common SpA subtype (76.4%), followed by nonradiographic axial

SUBMITTER: Yuce Inel T 

PROVIDER: S-EPMC12558185 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature