QTc prolongation and torsades de pointes (TdP) in individuals undergoing methadone maintenance treatment (MMT): A systematic review and meta-analysis.

ABSTRACT:

Background

The incidence of corrected QT interval (QTc) prolongation and torsades de pointes (TdP) in individuals undergoing methadone maintenance treatment (MMT) is a significant concern, as studies indicate that methadone can lead to these cardiac complications.

Methods

A systematic search was performed across various databases including PubMed, Scopus, and Embase from January 2000 to July 2025. Risk of bias was assessed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) for observational studies.

Results

Twenty-two observational studies were included. The pooled mean age of patients undergoing MMT across the included studies was 40.8 years (95% confidence interval [CI]: 37.9-43.8). The overall pooled proportion of male participants across

SUBMITTER: Paknahad MH 

PROVIDER: S-EPMC12558210 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature