Comprehensive mendelian randomization analysis of human plasma proteome to identify potential drug targets for essential tremor.

ABSTRACT: We performed a systematic causal analysis of the plasma proteome, to discover potential protein markers and therapeutic targets for essential tremor (ET). Protein quantitative trait loci (pQTLs) of 4853 plasma proteins were derived from 7 published genome-wide association studies of the plasma proteome. A 2-sample Mendelian randomization (MR) study was conducted to assess the potential causal relationships between 4853 plasma proteins and ET. Summary-data-based MR and Bayesian colocalization analyses were performed to confirm the causal roles of the candidate proteins. Phenome-wide-MR (Phe-MR) was used to assess the selected potential side effects. Two-sample MR and Summary-data-based MR predicted that 6 targets were associated with ET: antioxidant 1 copper chaperone (ATOX1), carbonic anhy

SUBMITTER: Ma L 

PROVIDER: S-EPMC12558214 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature