Efficacy and safety of methylprednisolone in the prevention of seroma formation after mastectomy: Systematic review and meta-analysis.

ABSTRACT:

Background

Seroma, a common post-mastectomy complication linked to surgical inflammation, may be mitigated by anti-inflammatory agents such as methylprednisolone.

Methods

This meta-analysis evaluates methylprednisolone's efficacy and safety in preventing seroma. We systematically searched PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and other Chinese databases for randomized controlled trials (RCTs) (from inception to March 2025) involving methylprednisolone use post-mastectomy. Two reviewers independently screened studies, extracted data, and assessed bias using ROB 2.0 and GRADE. Outcomes included seroma incidence, drainage metrics, wound complications, and seroma grading. Data were analyzed via Review Manager and Trial Sequent

SUBMITTER: Xiong X 

PROVIDER: S-EPMC12558233 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature