Association of the serum uric acid-to-HDL-cholesterol ratio with kidney stones in U.S. adults: A cross-sectional study (NHANES 2007-2016).

ABSTRACT: Whether the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is associated with kidney-stone risk remains unknown. This study was a cross-sectional analysis of 11,073 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2016. Information on kidney stone history was obtained via a self-reported questionnaire. The UHR was calculated as follows: (uric acid mg/dL ÷ high-density lipoprotein cholesterol mg/dL) × 100%. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) per one-unit UHR increase and across UHR tertiles, adjusting for sociodemographic factors, comorbidities, and metabolic covariates. Restricted cubic splines were used to determine the dose-response and potential breakpoint

SUBMITTER: Yu J 

PROVIDER: S-EPMC12558274 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature