Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, low-grade chronic inflammation, and insufficient insulin secretion, influenced by genetic predisposition and detrimental lifestyle choices. It leads to severe complications that significantly impair quality of life. Sang Huang, a rare and valuable medicinal fungus, has potential therapeutic value for T2DM, but its mechanisms remain underexplored. This study utilized network pharmacology to investigate Sang Huang therapeutic potential in T2DM, validated core targets via molecular docking and molecular dynamics simulations, and elucidated its mechanisms. Results demonstrated that estradiol dipropionate (EDP), a key component of Sang Huang, exerted anti-T2DM effects via pathways such as PI3K-A

SUBMITTER: Li H 

PROVIDER: S-EPMC12558310 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature