Cerebrospinal fluid metabolomic and postpartum depression: A Mendelian randomization study.

ABSTRACT: Postpartum depression (PPD) is a multifaceted mental health disorder manifesting as enduring sadness, anxiety, and exhaustion following childbirth. Emerging evidence points to a metabolic dimension in its pathology. Our research examines the causal links between cerebrospinal fluid (CSF) metabolites and PPD via Mendelian randomization (MR). A bi-directional MR framework was applied to explore the causative connections between 338 CSF metabolites and PPD. The study harnessed data from 2 targeted genome-wide association studies: one encompassing single nucleotide polymorphism data from mothers diagnosed with PPD, and another concerning CSF metabolite profiles, both centered on European descendants. Instrumental variables from these datasets were meticulously selected to enhance MR analysis'

SUBMITTER: Hong M 

PROVIDER: S-EPMC12558325 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature