Genetic variation in targets of granulocyte colony-stimulating factor drugs and 14 cancers risk: A Mendelian randomization study.

ABSTRACT: Previous studies suggest that granulocyte colony-stimulating factor (G-CSF) drugs may increase the risk of certain cancers, but findings remain controversial. We employed a drug-target Mendelian randomization approach to investigate the causal relationship between G-CSF and 14 cancer types. The target gene of G-CSF drugs was sourced from the DrugBank database. Expression quantitative trait loci data for the target gene (CSF3R) were obtained from the expression quantitative trait loci Gen Consortium. Genome-wide association study data for the 14 cancers were retrieved from the FinnGen dataset. A Bonferroni correction was applied for multiple testing (P < .0036). Analyses were performed using the inverse variance weighted, Mendelian randomization-Egger, weighted median, weighted mode, and si

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12558334 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature