Of mice and men: translating mouse knockout models of human male infertility.

ABSTRACT: Infertility is a global health issue affecting a significant portion of couples, estimated at ∼10-15% of reproductive-aged couples worldwide, with the World Health Organisation (WHO) suggesting roughly one in six (∼17.5%) of the adult population experiences infertility. Male causes of infertility are attributable as a sole or leading cause in 40-50% of cases. Furthermore, sperm/semen counts have plummeted by ∼60% over the past 50-60 years in males attending fertility clinics. There is thus an urgent need to understand the causes behind these numbers to address such worrying trends. However, human male infertility is a heterogeneous and often idiopathic condition, with genetic factors increasingly recognised as major contributors. In this review, we examine known and emerging genetic causes

SUBMITTER: Barada S 

PROVIDER: S-EPMC12558365 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature