Elastin-like polypeptide delivery of an NF-kB inhibitor for treatment of juvenile mild TBI complicated by high-fat diet consumption.

ABSTRACT: Juveniles are at increased risk for mild traumatic brain injury (mTBI) due to recreational activities, domestic violence, and vulnerabilities of the developing skull. In industrialized nations, adolescents often consume high-sugar, high-fat diets (HFD), which can impair CNS health and exacerbate mTBI outcomes. Secondary injury following mTBI is characterized by prolonged neuroinflammation, with nuclear factor kappa B (NF-κB) acting as a central regulator of these inflammatory responses. We developed a polypeptide biologic, SynB1-ELP-p50i, consisting of an elastin-like polypeptide delivered NF-κB inhibitor (p50i) and the cell-penetrating peptide SynB1. This study investigates the interaction between diet and NF-κB inhibition in juvenile rats with mTBI by examining SynB1-ELP-p50i biodistribu

SUBMITTER: Haskell JP 

PROVIDER: S-EPMC12558432 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature