Machine learning reveals distinct T-cell receptor clusters in plasma cell dyscrasias compared to healthy controls.

ABSTRACT: T-cell receptor (TCR) repertoire diversity has been implicated in the progression and prognosis of multiple myeloma (MM). This study aimed to evaluate the association between T-cell clonality, immune response, and clinical outcomes in patients with plasma cell dyscrasias using next-generation sequencing of the TCR β chain (TCRB). TCRB sequencing was performed on peripheral blood samples from patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and newly diagnosed multiple myeloma (MM). Healthy individuals served as controls. No significant differences in TCR repertoire diversity were observed between healthy individuals and those with MGUS, SMM or MM after adjusting for age. Furthermore, TCR diversity did not correlate with treatment r

SUBMITTER: Coffey DG 

PROVIDER: S-EPMC12558469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature