Development and characterisation of fast dispersible dimenhydrinate tablets: Compactional study and in-silico PBPK modeling.

ABSTRACT: The aim of this study was to optimize and evaluate dimenhydrinate fast dispersible tablets (50 mg) by utilizing cost effective direct compression method. A total of nine formulations (F1-F9) were designed and developed by central composite rotatable design using design expert® software (version 11.0, Stat-Ease Inc.,) to study the impact of avicel PH102 (15-55%) and sodium starch glycolate (2-8%) on responses, i.e., hardness (R1), disintegration time (R2) and % drug release (R3). Powder blends of all formulations showed good flow behavior. Post compressional studies were conducted to assess the quality attributes of the compressed formulations. Formulation F2 was found to be optimized with good mechanical strength, i.e., hardness 4.2 kg, friability 0.77%, disintegration time 19 secs and % d

SUBMITTER: Maqbool U 

PROVIDER: S-EPMC12558512 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature