Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions.

ABSTRACT:

Background

When designing clinical trials, interpreting trial outcomes for guideline development or sharing decisions with patients in clinical practice, the clinical outcomes used and the implicit choices on what constitutes a clinically significant finding can vary greatly. This can lead to diversity or even inequity in care offered to patients with inflammatory bowel disease (IBD). The GRADE approach to guideline development has proposed a process to address this prospectively to solve these issues, but this has never been used in IBD. We aimed to develop the first international consensus set of outcome thresholds to establish their use in Crohn's disease and ulcerative colitis.

Methods

A Delphi methodology was used to develop a consensus. An online survey was conducted b

SUBMITTER: Gordon M 

PROVIDER: S-EPMC12558582 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature