Identification of key genes for heart failure in dilated cardiomyopathy in different populations.

ABSTRACT:

Background

Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the development of HF across diverse populations and among different genders.

Methods

This study strictly included five datasets of HF with dilated cardiomyopathy: GSE141910 (African American and Caucasian), GSE57345 (USA), GSE21610 (Germany), GSE17800 (Germany), and GSE42955 (Spain). These datasets were merged and normalized as the validation set. Differentially expressed genes (DEGs) were identified through differential expression analysis, and module genes were identified using weighted gene co-expression network analysis. Subsequent stratification by

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12558640 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature