Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice.

ABSTRACT: Endotherms increase the rate of metabolism in metabolic organs as one strategy to cope with a decline in the temperature of the external environment. However, an additional major contributor to maintenance of body temperature in a cold environment is contraction-based thermogenesis in skeletal muscle. Here, we show that impairment of hind limb muscle contraction by cast immobilization induced a loss of function of skeletal muscle and activated brown adipose tissue (BAT) thermogenesis as a compensatory mechanism. BAT utilizes free branched-chain amino acids (BCAAs) derived from skeletal muscle as an energy substrate for thermogenesis, and interleukin-6 released by skeletal muscle stimulates BCAAs production in muscle for support of BAT thermogenesis. Additionally, this thermoregulatory syst

SUBMITTER: Izumi-Mishima Y 

PROVIDER: S-EPMC12558653 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature