Cancer outcomes of pregnancy after diagnosis of breast cancer in premenopausal women: an updated systematic review and meta-analysis.

ABSTRACT:

Introduction

Breast cancer is a type of hormone-driven cancer, and pregnancy may increase the risk of recurrence in patients due to hormone surge. Our study was designed to explore the cancer outcomes of premenopausal women who had primary breast cancer and who became pregnant at any time after diagnosis.

Methods

Searches were conducted in ten databases until July 2024, with no language restrictions. We analyzed aggregate data across all study populations and performed subgroup analyses by stage, estrogen receptor status, BRCA mutation status, HER2 status, previous treatment, lymph node status, interval between pregnancy and diagnosis, pregnancy type, reproductive status, and breastfeeding status.

Results

Fifty-two studies were included. The pregnancy group had longer

SUBMITTER: Mei H 

PROVIDER: S-EPMC12558755 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature