The kinetic behavior of matrine in pig intestinal lumen after oral administration and its physiologically based pharmacokinetic modeling.

ABSTRACT:

Introduction

Matrine (MT) has been found to restore the susceptibility of Escherichia coli to a variety of antibiotics in vitro. Nevertheless, the absence of pharmacokinetic data makes it uncertain whether MT exhibits efficacy in vivo. The study aimed to investigate the kinetic behavior of MT in pig intestinal lumen, the primary site for the colonization of enterotoxigenic Escherichia coli, and to develop a minimal physiologically based pharmacokinetic (PBPK) model for MT in pig intestinal lumen.

Methods

Two animal experiments were carried out for these purposes. In experiment 1, 12 pigs were implanted with a sterile T-cannula, and then were given a single oral dose of MT or MT-Amoxicillin (AMO) combination at 40 or 70 mg/kg. In experiment 2, 25 pigs wer

SUBMITTER: Yang B 

PROVIDER: S-EPMC12558759 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature