Anti-neoplastic effects of the antipsychotic drug penfluridol in preclinical prostate cancer models.

ABSTRACT:

Introduction

The development of therapy resistance and the formation of distant metastases represent clinical unmet needs for patients with advanced prostate cancer (PCa). The use of drugs for other indications, i.e. drug repurposing, shows great promise for cancer treatment. Drug repurposing could allow new cancer treatments to be introduced relatively quickly and at lower costs. Penfluridol, an approved antipsychotic drug, has strong cytolytic effects in multiple cancers.

Methods

In this study, we have investigated the potential anti-tumor effects of penfluridol in preclinical and 'near-patient' PCa models.

Results

Penfluridol significantly reduced the viability of a panel of human PCa cells, induced apoptosis by increasing caspase-3/7 levels and decreased the numbe

SUBMITTER: van de Merbel AF 

PROVIDER: S-EPMC12558770 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature