Renal hyperfiltration with and without metabolic syndrome: differential implications for cardiovascular events, kidney failure, and mortality.

ABSTRACT:

Background

Renal hyperfiltration (RHF) and metabolic syndrome (MetS) share common pathophysiology and are both associated with adverse clinical outcomes. However, their combined impact remains unclear.

Methods

In total, 278,552 propensity score-matched individuals were enrolled in the Korean National Health Insurance Service database (2009-2011). Participants were divided into four groups based on RHF and MetS status, and cardiovascular (CV) events, end-stage kidney disease (ESKD) progression, and all-cause mortality were evaluated.

Results

Compared to non-MetS with normal renal filtration (NRF), MetS with NRF was associated with a significant increase in the risk of CV events, which was further amplified when combined with RHF (adjusted HR = 1.44, 95% CI = 1.35-1.55,

SUBMITTER: Lee YH 

PROVIDER: S-EPMC12558771 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature