Comprehensive dietary antioxidant index and chronic kidney disease: mediating role of frailty and its impact on mortality outcomes in adults.

ABSTRACT:

Background

Chronic kidney disease (CKD) poses significant global health challenges, with oxidative stress and inflammation contributing to its pathogenesis. While dietary antioxidants may mitigate CKD risk, reflected by Comprehensive Dietary Antioxidant Index (CDAI), the mediating role of frailty (FI) remains underexplored. This study investigates the association between CDAI and CKD risk, with a focus on FI as a potential mediator and its implications for mortality outcomes.

Methods

Utilizing data from 11,904 U. S. adults in the National Health and Nutrition Examination Survey (NHANES, 2011-2018), we analyzed CDAI (comprising manganese, selenium, zinc, and vitamins A, C, E) and its association with CKD. Multivariable logistic regression, restricted cubic splines, and Cox pr

SUBMITTER: Li W 

PROVIDER: S-EPMC12558786 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature