The role of immune- and lipid metabolism-related genes in macrophage polarization and prognosis of glioblastoma.

ABSTRACT:

Objective

To investigate the roles of immune- and lipid metabolism-related genes in macrophage polarization and their prognostic and therapeutic implications in glioblastoma (GBM).

Methods

A total of 655 GBM samples from The Cancer Genome Atlas (TCGA) were stratified into immune and non-immune groups based on immune scores. Differentially expressed genes (DEGs) were identified, and their intersection with 859 lipid metabolism-related genes yielded 26 candidates. A 10-gene prognostic signature was constructed using univariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses and validated in both internal (TCGA) and independent (Chinese Glioma Genome Atlas, CGGA) cohorts. Functional enrichment, single-cell transcriptomic analysis, experimenta

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12558797 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature