Association between systemic inflammation response index trajectories and carotid atherosclerosis progression.

ABSTRACT:

Background

The systemic inflammation response index (SIRI) has emerged as a promising inflammatory biomarker linked to the onset and progression of cardiovascular disease (CVD). However, the association between initial and long-term trajectories of the SIRI index and carotid atherosclerosis (CAS) progression remains unexplored.

Methods

This longitudinal retrospective cohort study encompassed 11,623 adults undergoing multiple general health checks at Taizhou Hospital of Zhejiang Province from January 2017 to September 2024. SIRI values were derived using the formula: neutrophil count × monocyte count/lymphocyte count. To assess SIRI trends over time, latent class trajectory modeling was utilized. Hazard ratios (HRs) and 95% confidence intervals (CIs) for both the initial and

SUBMITTER: You N 

PROVIDER: S-EPMC12558823 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature