20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in <i>Caenorhabditis elegans via</i> the insulin/IGF-1 signaling pathway.

ABSTRACT:

Introduction

Aging is a progressive and irreversible process linked to a variety of diseases. Examination of the processes targeted by pharmacological treatments could potentially both extend lifespan and alleviate age-associated diseases. 20(S)-protopanaxadiol (20(S)-PPD), a primary ginsenoside metabolite, has many beneficial properties, although it`s anti-aging effects are unknown.

Methods

Lifespan and behavioral assays were used to determine the effects of 20(S)-PPD on life span and healthy lifespan. Stress resistance was systematically determined under heat, oxidative, and chemical stress conditions. The target of 20(S)-PPD was identified by molecular docking and surface plasmon resonance. Investigation in mutant worms identified the signaling pathway and transcription f

SUBMITTER: Song Z 

PROVIDER: S-EPMC12558884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature