SFGL2 as a Potential Immunosuppressive Biomarker Associated With COVID-19 Severity in Kidney Transplant Recipients.

ABSTRACT:

Background

SARS-CoV-2 infection can induce persistent immunosuppression. Soluble fibrinogen-like protein 2 (sFGL2) is an emerging immune regulator. However, the correlation between sFGL2 and SARS-CoV-2-induced immunosuppression in kidney transplant recipients (KTRs) remains unclear.

Materials and methods

sFGL2 levels and peripheral blood lymphocyte subpopulations (PBLSs) were measured simultaneously in 50 KTRs with COVID-19 on Day 1 and Day 7 after admission. An additional cohort of 15 stable KTRs without COVID-19 was recruited as the control group. sFGL2 was quantified using enzyme-linked immunosorbent assay, and PBLSs were analyzed with 6-Color TBNK Reagent and quantified by flow cytometry.

Results

sFGL2 levels in the COVID-19 group were significantly higher than th

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12558890 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature