Cardioprotective effects of <i>Bassia indica</i> via NF-κB and BCL-2/BAX modulation in isoproterenol-induced myocardial injury.

ABSTRACT:

Background

Myocardial infarction (MI) is a fatal coronary heart disease that develops due to prolonged hypoxia. During MI progression, uncontrolled inflammation and apoptosis mediated by NF-κB and BAX/BCL-2 signaling pathways potentiate cardiac injury. Phenolic and flavonoid-rich medicinal plants have shown efficacy in suppressing the inflammatory pathways, thus reducing the adverse cardiac remodeling. In this study, we evaluated the cardioprotective and anti-inflammatory potential of Bassia indica (Wight) A.J. Scott, a plant traditionally used for treating cardiac disorders.

Methods

B. indica extract (BiE) was prepared and characterized by UHPLC-MS/MS. Its anti-inflammatory activity was determined by in vitro inhibition of COX-2 and 5-LOX enzymes, follo

SUBMITTER: Anjum F 

PROVIDER: S-EPMC12558898 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature