PLSCR1 Regulates the Physiology of Fibroblast-Like Synoviocytes via Modulating the STAT1 Signaling Pathway.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Elucidating the molecular mechanisms underlying the pathogenesis is crucial for identifying novel therapeutic targets. Phospholipid scramblase 1 (PLSCR1) has been implicated in systemic autoimmune diseases. However, the function and underlying mechanism in RA remains unclear.

Methods

Reverse transcriptase-quantitative polymerase chain reaction was used to detect the expression levels of PLSCR1 in the serum of 30 RA patients and 30 healthy controls. The function of PLSCR1 in human fibroblast-like synoviocytes (HFLSs) was investigated by siRNA-mediated knockdown. Cell proliferation, apoptosis, and inflammatory cytokine production were assessed thro

SUBMITTER: Chen T 

PROVIDER: S-EPMC12558900 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature