The utility of CXCL13 and circulating CXCR5⁺ T cell detection in the diagnosis of systemic lupus erythematosus associated nephritis.

ABSTRACT:

Introduction

CXCL13 regulates the homing of lymphocytes. It is highly expressed in kidney and serum of SLE patients, and correlates with disease activity, but its value in LN is unclear. This study was to investigate the expression and diagnostic value of CXCL13 and its regulated CXCR5⁺ T cells in LN.

Methods

In mice, the association of serum CXCL13 levels with renal function was analyzed. And CXCR5⁺ T cell was detected by H&E staining and immunofluorescence in kidney, and by flow cytometry in spleen. In clinical studies, the association of CXCL13 and CXCR5⁺ T cells with disease activity was verified, and their diagnostic efficacy was assessed by ROC curves.

Results

CXCL13 was elevated in both mouse and patients, and was positively cor

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12558933 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature